Set in the near future, Marge is competently coping with the hormonal onslaught hitting her now teenage kids when she's suddenly struck by a big life change of her own, leaving Homer as the last sane person in the house... or is he?
Dan Castellaneta
Homer Simpson / Abe Simpson / Barney Gumble / Krusty (voice)
Julie Kavner
Marge Simpson / Patty Bouvier / Selma Bouvier (voice)
Nancy Cartwright
Bart Simpson / Nelson Muntz / Ralph Wiggum (voice)
Yeardley Smith
Lisa Simpson (voice)
Hank Azaria
Moe Szyslak / Chief Wiggum / Apu / Comic Book Guy / Carl (voice)
Harry Shearer
Ned Flanders / Mr. Burns / Smithers / Skinner / Lenny (voice)
Jon Lovitz
Artie Ziff (voice)
Kevin Michael Richardson
Dr. Hibbert (voice)
Megan Mullally
Sarah Wiggum (voice)
Maggie Roswell
Helen Lovejoy / Luann Van Houten (voice)
Tress MacNeille
(voice)
Chris Edgerly
(voice)
Kelly MacLeod
Milhouse Van Houten (voice)
Kimberly Brooks
Carrie (voice)
Grey DeLisle
Sherri Mackleberry (voice)
Dawnn Lewis
Bernice Hibbert / Pam / Perimenopause: The Musical Singer (voice)
Jenny Yokobori
Female Doctor (voice)
Lindsay Lohan
Maggie Simpson (voice)