Izzie and George's new-founded relationship results in them having bad sex. Callie's Chief Resident position is taken away from her, and Bailey is the humble replacement. Meredith can barely handle it with Lexie anymore.
Ellen Pompeo
Meredith Grey
Chandra Wilson
Miranda Bailey
Sandra Oh
Cristina Yang
Justin Chambers
Alex Karev
James Pickens Jr.
Richard Webber
Patrick Dempsey
Derek Shepherd
Katherine Heigl
Izzie Stevens
Sara Ramirez
Callie Torres
Eric Dane
Mark Sloan
Chyler Leigh
Lexie Grey
Brooke Smith
Erica Hahn
Jeff Perry
Thatcher Grey
David Burke
Don
Mark Saul
Steve
Stephanie March
Jane
Vicki Lewis
Harriet
Rockmond Dunbar
Sean Brotherton
Enuka Okuma
Teresa Brotherton
Kurt Fuller
Jerry
Amrapali Ambegaokar
Intern Dani
Linda Eve Miller
ER Nurse
Braeden Lemasters
Brian
